Experimental Physiology
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Quarterly Journal of Experimental Physiology 12.4 pp 339-346
© The Physiological Society 1920
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RESEARCHES ON THE PERFUSED HEART: ITS MODE OF WORKING

W. Burridge M.A.,M.B.1

1 The Physiological Laboratory, Oxford

1. The heart perfused with Ringer's solution may be likened to a machine working without lubricant.

2. The normal lubricant is adrenin, and it facilitates certain actions of calcium.

3. Since blood contains adrenin and Ringer's solution does not, the calcium tension of Ringer's solution must be higher than that of blood, to compensate for the absence of adrenin.

4. The fresh heart perfused with Ringer's solution beats approximately at its maximum amplitude of contraction.

5. The system thus formed is of a low order of flexibility.

6. A method of increasing its flexibility is described.

7. A method is also described for obtaining results directly comparable from heart to heart.

In conclusion, I wish to express my indebtedness to Professor Sherrington for the facilities afforded me to carry out the work.






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Copyright © 1920 by the The Physiological Society.