Experimental Physiology
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Quarterly Journal of Experimental Physiology 21.3 pp 217-225
© The Physiological Society 1931
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THE CAUSATION OF MUCIFICATION AND CORNIFICATION IN THE VAGINA OF THE MOUSE

J. M. Robson 1 and B. P. Wiesner 1

1 Macaulay Laboratory, Institute of Animal Genetics, The University, Edinburgh

(1) An extract of corpus luteum of cow produces either cornification or mucification of the vaginal epithelium of mature oöphorectomised mice, according to the dose administered.

(2) Saponified extracts from pregnancy urine and extracts from follicular fluid, containing agr-hormone, can produce cornification or mucification according to the dosage.

(3) The mucifying dose of agr-hormone is about one-quarter to one-half of the cornifying dose.

(4) The production by agr-hormone of either cornification or mucification does not depend only on the total quantity of hormone administered but also on the concentration of agr-hormone in a dose. The conditions for the summation effect in mucification and cornification are discussed.

Submitted on July 11, 1931






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Copyright © 1931 by the The Physiological Society.