Experimental Physiology
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Quarterly Journal of Experimental Physiology 21.3 pp 281-287
© The Physiological Society 1931
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THE RESPONSES OF THE EXCISED BATRACHIAN ALIMENTARY CANAL TO AUTONOMIC DRUGS. EPHEDRINE

David Epstein 1

1 Department of Pharmacology, University of Cape Town

1. Ephedrine is unable to cause inhibition of the excised amphibian alimentary canal.

2. When the ratio of the concentration of ephedrine to that of adrenaline is as 1000 to 1, ephedrine antagonises or prevents the adrena-

line (i.e. sympathetic) inhibition. This antagonism appears to have no connection with the efferent sympathetic or the parasympathetic systems.

3. Ephedrine is unable to antagonise the excitatory or the inhibitory effects of arecoline on amphibian alimentary tissues.

4. The latter observation suggests that the arecoline relaxation of the intestine of Rana is not the result of sympathetic stimulation, and favours the inhibitory parasympathetic hypothesis.

5. In the intestine of Rana ephedrine may sometimes produce a reversal of the inhibitory effects of adrenaline.

The author wishes to thank Professor J. W. C. Gunn for his interest in this investigation.

Submitted on August 17, 1931






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Copyright © 1931 by the The Physiological Society.