Experimental Physiology
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Quarterly Journal of Experimental Physiology 24.4 pp 377-382
© The Physiological Society 1935
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THE EFFECT OF IODOACETATE ON POST-MORTEM GLYCO-GENOLYSIS IN LIVER

H. R. Noltie 1

1 The Department of Physiology, University of Aberdeen

1. lodoacetate did not prevent glycogenolysis in rabbit liver slices, incubated in nitrogen at 38°, either when injected prior to decapitation or when in the suspending medium.

2. lodoacetate caused the lactic acid concentration to become stationary, but required one to two hours to achieve complete inhibition.

3. lodoacetate did not prevent accumulation of sugar, although it appears to have exerted a braking effect on its production.

The author wishes to record his thanks to Professor J. J. R. Macleod for his interest and advice; and to the Medical Research Council for assistance from their grant to Professor Macleod and Dr J. M. Peterson.

Submitted on November 22, 1934






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Copyright © 1935 by the The Physiological Society.