Experimental Physiology
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Quarterly Journal of Experimental Physiology 25.3 pp 259-265
© The Physiological Society 1935
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SYNERGY OF ADRENALINE AND ACETYLCHOLINE ON THE PULMONARY BLOOD-VESSELS IN THE RABBIT

G. Harold Ettinger 1 and G. Edward Hall 1

1 The Department of Medical Research, Banting Institute, University of Toronto

1. Acetylcholine is capable of producing powerful constriction of the pulmonary blood-vessels in the rabbit.

2. The constriction depends upon an initial tone of the blood-vessels.

3. In the perfused blood-vessels repeated injections of acetylcholine produce a condition in which the muscle fails to respond, probably because acetylcholine promotes dilatation following the constriction. The sensitivity, i.e. the muscle tone, may be restored by adrenaline, barium or histamine.

4. In the living animal the tone is probably mediated by the sympathetic nerves or by adrenaline.

5. The hypothesis is offered that major changes in the calibre of the pulmonary artery and arterioles of the rabbit are brought about through parasympathetic activity.

Submitted on July 7, 1935






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Copyright © 1935 by the The Physiological Society.