Experimental Physiology
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Quarterly Journal of Experimental Physiology 26.1 pp 13-27
© The Physiological Society 1936
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THE ACTION ON PERFUSED LUNGS OF DRUGS INJECTED INTO THE BRONCHIAL VASCULAR SYSTEM

P. Alcock 1, J. L. Berry 1, I. de Burgh Daly 1, and B. Narayana 1

1 The Physiology Departments, Universities of Birmingham and Edinburgh

In the entire animal under positive pressure respiration and in the isolated lungs of the dog under negative pressure ventilation, with perfusion of the pulmonary and bronchial vascular system, injections of histamine and adrenaline into the bronchial circulation cause a tidal air diminution and augmentation respectively.

A constriction of the respiratory tract produced by histamine injected into the pulmonary or bronchial circulation is, in general, partially or completely released by adrenaline injected into the bronchial or pulmonary circulation respectively.

We are indebted to Dr. E. L. Godfrey for the radiograph shown in fig. 6.

The expenses of the research have been defrayed by a grant to one of us [I. de B. D.] from the Government Grant Committee of the Royal Society, to whom we express our thanks.

Submitted on December 9, 1935






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Copyright © 1936 by the The Physiological Society.