Experimental Physiology
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Quarterly Journal of Experimental Physiology 26.2 pp 127-139
© The Physiological Society 1936
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ANTI-CURARE ACTION OF POTASSIUM AND OTHER SUBSTANCES

A. T. Wilson 1 and Samson Wright 1

1 The Department of Physiology, Middlesex Hospital, London, W. 1.

1. The effects of intra-arterial injection of potassium chloride, prostigmine, adrenaline and acetyl-choline on normal, curarised and denervated skeletal muscle are described.

2. Potassium ions are shown to have a striking anti-curare action with distinctive characteristics, differing in important respects from that produced by the other drugs named.

3. The action of potassium in antagonising fatigue in striped muscle is very slight. The same is the case with prostigmine. These findings and other results recorded in the literature suggest that the mechanism of curare action and that of fatigue in striped muscle differ in fundamental respects.

Submitted on May 20, 1936






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Copyright © 1936 by the The Physiological Society.