REACTIVITY OF THE THYROID OF THE RABBIT TO THE THYROTROPIC HORMONE OF THE ANTERIOR PITUITARY

¹ Pharmacology Department, King George's Medical College, Lucknow, U.P., India. The Department of Pharmacology, University of Edinburgh

1. Administration of thyrotropic hormone definitely increased the basal metabolic rate of the normal, the partially hypophysectomized, and the completely hypophysectomized rabbits.

2. The increase in the metabolic rate did not appear before the fourth day of injections in animals receiving subcutaneous injection. The animals receiving intra-muscular injection showed an earlier rise in metabolism.

3. Hypophysectomy lowers the metabolic rate.

I am very grateful to Professor A. J. Clark, F.R.S., for giving me the opportunity to work in his Department and to Dr J. M. Robson for doing the operative procedures and giving me advice, help, and guidance throughout.