Experimental Physiology Celebrating 100 years
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Quarterly Journal of Experimental Physiology 26.4 pp 375-392
© The Physiological Society 1937
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Clark, A. J.
Right arrow Articles by Raventós, J.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Clark, A. J.
Right arrow Articles by Raventós, J.

THE ANTAGONISM OF ACETYLCHOLINE AND OF QUATERNARY AMMONIUM SALTS

A. J. Clark 1 and J. Raventós 1

1 The Department of Pharmacology, University of Edinburgh

1. The study of a number of antagonists in a variety of tissues shows that all drugs which antagonise acetylcholine also antagonise Me4N.

2. The concentration of antagonist needed in any tissue to produce an equal intensity of antagonism is similar with acetylcholine and with Me4N.

3. A considerable proportion of the antagonism studied between drugs termed A and B approximate to the simple relation [A]/[B]=constant. A certain proportion of antagonisms deviate from this relationship.

4. A considerable proportion of the facts observed can be interpreted on the assumption that antagonistic drugs compete for a common receptor.

The expenses of this research were in part defrayed by a grant from the Moray Fund, and the cost of illustrations by a grant from the Carnegie Trust, for both of which we express our thanks.

Submitted on March 3, 1937






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1937 by the The Physiological Society.