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Quarterly Journal of Experimental Physiology 27.2 pp 147-160
© The Physiological Society 1937
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A FACTOR INHIBITING THE GROWTH OF MESENCHYME

P. B. Medawar 1

1 The Sir William Dunn School of Pathology, Oxford

1. The work of Heaton on a factor present in malt extracts which inhibits the growth of connective tissue is confirmed.

2. The action of the factor on explants of heart, spleen, buffy coat, periosteum, perichondrium, Jensen Rat Sarcoma, etc., indicates that it extends to all mesenchyme derivatives.

3. It is shown to be a constituent of normal diet; and its dietic status is discussed.

4. A survey of its manner of action on explanted tissues is reported, and a method of assay described.

5. The factor is shown to have no demonstrable direct effect on the growth of epithelia.

6. The meaning to be attached to the term "growth-inhibition" is discussed.

The author wishes to thank Professor H. W. Florey, Mr. J. Z. Young, and Dr. H. M. Carleton for their interest in this work and for their advice. He also wishes to thank the Christopher Welch Trust for the supply of certain apparatus.

Submitted on June 2, 1937






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Copyright © 1937 by the The Physiological Society.