Experimental Physiology Celebrating 100 years
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Quarterly Journal of Experimental Physiology 27.2 pp 161-170
© The Physiological Society 1937
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lees, J. C.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Lees, J. C.

THE INHIBITION OF GROWTH BY 1·2 : 5·6 DIBENZANTHRACENE AND OTHER AGENTS

J. C. Lees 1

1 The Department of Pharmacology, University of Edinburgh

1. Single injections of 5, 10, and 20 mg. 1·2 : 5·6 dibenzanthracene produce a prolonged inhibiting effect on the growth of young rats, and the effect produced varies as the dosage.

2. Mercury in oil, bismuth salicylate in oil, and thallium acetate in single injections produce an immediate but transient interference with growth.

3. Various non-carcinogenic polycyclic hydrocarbons produce an immediate but transient interference with growth.

4. Nearly half (21/48) of the animals injected with d.b.a. died within 64 days. Half the deaths (11/21) occurred between 40 and 64 days after injection.

This work was made possible by a grant from the Medical Research Council for the maintenance of animals and laboratory expenses, and by a personal grant from the Cancer Control Organisation for South-East Scotland. Thanks are also due to Dr. C. M. Scott for advice and assistance.

Submitted on June 8, 1937






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1937 by the The Physiological Society.