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Quarterly Journal of Experimental Physiology 27.2 pp 171-180
© The Physiological Society 1937
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THE ACTION OF 1·2 : 5·6 DIBENZANTHRACENE ON THE METABOLISM OF RATS

J. C. Lees 1

1 The Department of Pharmacology, University of Edinburgh

1. Injection of 10 mg. followed by 15 mg. of 1·2 : 5·6 dibenzanthracene in adult rats did not alter the metabolic rate or the food consumption.

2. These injections, however, produced a prolonged loss of weight and death in 4 out of 8 rats. The deaths occurred 42 to 65 days after injection.

3. The inhibition of the growth of young rats by 1·2 : 5·6 dibenzanthracene was not affected by treating the rats with thyroid or insulin.

4. 1·2 : 5·6 dibenzanthracene in large doses did not affect normal cestrus in rats.

This work was made possible by a grant from the Medical Research Council for the maintenance of animals and laboratory expenses, and by a personal grant from the Cancer Control Organisation for South-East Scotland. Thanks are also due to Dr. C. M. Scott for advice and assistance.

Submitted on June 8, 1937






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Copyright © 1937 by the The Physiological Society.