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Quarterly Journal of Experimental Physiology and Cognate Medical Sciences 28.1 pp 71-75
© The Physiological Society 1938
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ANTAGONISM OF THE VAGINAL ACTION OF TRIPHENYL ETHYLENE BY PROGESTERONE AND TESTOSTERONE

J. M. Robson 1

1 Department of Pharmacology, University of Edinburgh

The vaginal cornification produced by the synthetic oeligstrogen, triphenyl ethylene, in spayed mice is inhibited when progesterone or testosterone propionate is simultaneously administered. Testosterone is more effective than progesterone in producing this inhibition, and the results are quantitatively similar to those obtained for the antagonism between the naturally occurring oeligstrogen, oeligstrone, and progesterone and testosterone.

The expenses of this investigation have been defrayed by a grant from the Medical Research Council.

Submitted on April 25, 1938






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Copyright © 1938 by the The Physiological Society.