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Quarterly Journal of Experimental Physiology and Cognate Medical Sciences 28.2 pp 177-193
© The Physiological Society 1938
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RELEASE OF ACETYLCHOLINE BY VAGAL STIMULATION

A. J. Clark 1 and J. Raventós 1

1 Department of Pharmacology, University of Edinburgh

1. The rate of recovery of the frog's auricle wetted with a small volume of solution of Ac.Ch. has been compared with the rate of recovery from vagal stimulation. The latter is about five times as rapid as the former.

2. Comparison of the intensity of action of vagal stimulation and of Ac.Ch. solutions indicates that vagal stimulation causes a local concentration of Ac.Ch. of a few parts per 100 million.

3. Summation effects observed with vagal stimulation can be accounted for by assuming the rate of hydrolysis indicated by other experiments.

4. The duration of the slow response of skeletal muscles to Ac.Ch. indicates an esterase activity not more than ten times greater than that of the auricle.

The expenses of this research were defrayed by a grant from the Moray Research Fund of Edinburgh University, and one of the authors (J. R.) is in recept of a grant from Messrs. Imperial Chemical Industries Ltd. We desire to express our thanks for this help.

Submitted on June 14, 1938






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Copyright © 1938 by the The Physiological Society.