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Quarterly Journal of Experimental Physiology and Cognate Medical Sciences 28.2 pp 195-205
© The Physiological Society 1938
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MECHANISM OF OEligSTRUS INHIBITION IN THE MOUSE DURING PREGNANCY

J. M. Robson 1

1 Department of Pharmacology, University of Edinburgh

1. A method for the quantitative estimation of vaginal smears is described.

2. The vaginal changes following the administration of various doses of coeligstradiol to pregnant mice have been quantitatively studied and compared with the vaginal effects produced by the administration of similar doses of oeligstradiol to spayed mice under the influence of progesterone or testosterone propionate.

3. The results suggest that in the pregnant mouse a concentration of progesterone is present similar to that produced by the daily administration of 1·5 mg. of the luteal hormone. There is evidence that a certain quantity of this hormone is produced outside the ovary.

The expenses of this investigation have been defrayed by a grant from the Medical Research Council.

Submitted on June 16, 1938






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Copyright © 1938 by the The Physiological Society.