Experimental Physiology
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Quarterly Journal of Experimental Physiology and Cognate Medical Sciences 28.4 pp 323-333
© The Physiological Society 1938
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THE RELATIVE IMPORTANCE OF KETOSIS AND ACIDOSIS IN THE PRODUCTION OF DIABETIC COMA

R. Schneider 1 and H. Droller 1

1 Department of Pharmacology, University of Sheffield

1. Acetoacetic acid and its sodium salt administered by continuous intravenous infusion to rabbits produced a state resembling diabetic coma with normal or relatively high alkali reserves.

2. beta-hydroxybutyric acid did not produce coma even at low alkali reserves.

3. Hydrochloric acid with one exception produced coma only at low alkali reserves.

4. It is concluded that diabetic coma is due in the main to a specific intoxication by the acetoacetic anion.

The authors desire to express their thanks to Professor E. J. Wayne at whose suggestion the work was undertaken, and to both him and Dr. H. A. Krebs for valuable advice and criticism: the latter also for the preparation of beta-hydroxybutyric and acetoacetic acid.

Submitted on September 1, 1938






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Copyright © 1938 by the The Physiological Society.