OBSERVATIONS ON THE BLOOD-PERFUSED LUNGS OF THE DOG, GUINEA-PIG, AND MACACUS RHESUS, WITH SPECIAL REFERENCE TO "SPONTANEOUS" LUNG MOVEMENTS

¹ Departments of Physiology, Universities of Birmingham and Edinburgh

The interpretation of venous outflow changes in organs perfused at constant volume inflow is discussed.

The recording system itself may be responsible for changes in venous outflow when a physiological alteration in inflow pressure takes place. The main error introduced is due to capacity changes in the manometer used for measuring the inflow pressure, and is such that if a pressor response is accompanied by a venous outflow augmentation, both being due to physiological events, the latter may be masked, or even reversed by reason of the transfer of a portion of the circulating fluid to the manometer.