Experimental Physiology
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Quarterly Journal of Experimental Physiology and Cognate Medical Sciences 28.4 pp 405-411
© The Physiological Society 1938
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HÆMOLYSIS AND THE MOBILISATION OF RED CELLS AFTER THE INTRAVENOUS INJECTION OF 30 PER CENT. NaCl

J. Douglas Robertson 1 and J. F. Barrett 1

1 Courtauld Institute of Biochemistry, Middlesex Hospital, W.1

1. Injection of 30 per cent. saline causes hæmolysis in cats and also in man (one observation). This hæmolysis also occurs in vitro and is therefore a direct action.

2. The hæmolysis interferes with the determination of blood volume by the vital red method. A method is described whereby plasma may be freed from hæmoglobin to allow determinations to be carried out by this technique.

3. A further effect of hypertonic salt is a mobilisation of red cells and hæmoglobin. When the animals are eviscerated and the liver excluded from the circulation this effect is virtually abolished.

Submitted on September 30, 1938






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Copyright © 1938 by the The Physiological Society.