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Quarterly Journal of Experimental Physiology and Cognate Medical Sciences 30.3 pp 245-248
© The Physiological Society 1940
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THE RATES OF ACTION AND CLEARANCE OF BARBITURATES

S. C. Das 1

1 Department of Pharmacology, University of Edinburgh

1. The rate of detoxication of quick-acting barbiturates in mice can be determined by the method of continuous intravenous infusion into the tail vein following a suitable initial dose.

2. The rate of detoxication of sodium evipan was found to lie between 1/28 to 1/35 of the quantity present per minute, and of pentothal sodium between 1/40 and 1/50.

3. Barbiturates such as barbitone, which produce a prolonged action, also act much more slowly than the labile barbiturates and hence the method described above does not give satisfactory results.

Submitted on February 7, 1940






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Copyright © 1940 by the The Physiological Society.