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Quarterly Journal of Experimental Physiology and Cognate Medical Sciences 33.4 pp 311-321
© The Physiological Society 1946
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RADIOGRAPHIC STUDIES OF THE EFFECTS OF MEPACRINE ON THE GASTRO-INTESTINAL TRACT OF THE RAT

Army Malaria Research Unit1 and The Nuffield Institute for Medical Research1

1 Oxford

1. A technique has been developed with which the effect of drugs on the gastro-intestinal tract may be studied in the intact unanæsthetised animal. The technique consists in giving rats bismuth meals and observing their rate of passage radiographically.

2. The effects of mepacrine on the rat's gut are: hypertonicity and disturbed peristalsis in the stomach; pylorospasm, increased gastric secretion; delay in gastric emptying; increased accumulation of gas in the stomach and the cæcum; and slight delay in the rate of passage of the bismuth meal through the small intestine.

3. The severity of the effect on the stomach may be measured by determining the length of time taken for the stomach to empty.

4. The effect of various doses of mepacrine dihydrochloride given before the barium meal has been determined, and this information will serve as a basis for comparative studies with other salts of this drug and with other methods of administration.

Submitted on May 8, 1945






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Copyright © 1946 by the The Physiological Society.