Experimental Physiology Celebrating 100 years
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Quarterly Journal of Experimental Physiology and Cognate Medical Sciences 36.3 pp 127-137
© The Physiological Society 1951
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Van Bekkum, D. W.
Right arrow Articles by Peters, R. A.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Van Bekkum, D. W.
Right arrow Articles by Peters, R. A.

OBSERVATIONS UPON A CHANGE IN AN ENZYMATIC PROCESS IN BURNS

D. W. Van Bekkum 1 and R. A. Peters 1

1 Department of Biochemistry, Oxford

1. A significant difference in the rate of deamination of DL-alanine by liver slices of rats has been found between unburned and burned animals at the height of the nitrogen loss in the urine. Deaminating power was determined by estimation of the (NH3 + urea) N formed.

2. The experiments presented suggest this difference to be of an enzymatic nature.

3. In the course of the work it was found that deamination of DL-alanine by liver slices was not influenced by the addition of glucose in vitro. Neither did a 24-hour fast with its consequent depletion of glycogen influence the deaminating activity of the liver in vitro.

4. The significance of the decreased deamination in burned animals' liver slices is discussed; it appears to be the first enzymatic change to be correlated with the loss of N in the urine.

Note:

Our thanks are due to Dr. E. H. Leach for histological help, and to Miss V. Bustin for technical assistance.

Submitted on September 19, 1950






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1951 by the The Physiological Society.