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Quarterly Journal of Experimental Physiology and Cognate Medical Sciences 45.1 pp 12-17
© The Physiological Society 1960
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THE ACTION OF CARBON TETRACHLORIDE ON THE SHEEP'S LIVER

F. Alexander 1 and D. C. Macdonald 1

1 Department of Veterinary Pharmacology, Royal (Dick) School of Veterinary Studies, University of Edinburgh

Changes in plasma alkaline phosphatase, proteins, serum calcium, blood sugar and BSP clearance were determined in sheep before and after the administration by mouth of 2 ml. carbon tetrachloride. Liver tissue was obtained by biopsy before and after the drug treatment and examined histologically. Carbon tetrachloride reduced the rate of clearance of BSP and the concentration of plasma proteins. Biopsy specimens taken after treatment showed histological evidence of damage. The histological changes were more marked in well-fed sheep. In experiments on a sheep with a biliary fistula no evidence was obtained of the excretion of carbon tetrachloride in the bile.

The results described support the hypothesis that the fasciocidal action of carbon tetrachloride is due to the liver damage produced by the drug and not a direct effect on the liver fluke.

Submitted on May 27, 1959






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Copyright © 1960 by the The Physiological Society.