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Quarterly Journal of Experimental Physiology and Cognate Medical Sciences 45.1 pp 50-54
© The Physiological Society 1960
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MAST CELL HISTAMINE AND THE ACCUMULATION OF COLLOID PARTICLES IN THE VASCULAR ENDOTHELIUM

T. Zemplényi 1, J. Fodor 1, and Z. Lojda 1

1 Institute for Cardiovascular Research Prague Krecaron, and the Embryological Institute, Charles University, Prague

The action of endogenous histamine, released from mast cells, on the uptake of colloid particles by the vascular elements of the rat mesentery was investigated. After the intraperitoneal administration of protamine sulphate, a marked accumulation of intravenously administered colloid Indian ink in the endothelium and perivascular histiocytes occurs. This process may be blocked by the antihistamine drug, Analergin. Particles of an intravenously injected fat emulsion, prepared from egg yolk, are also taken up by a similar mechanism.

Submitted on June 19, 1959






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Copyright © 1960 by the The Physiological Society.