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Quarterly Journal of Experimental Physiology and Cognate Medical Sciences 45.1 pp 72-76
© The Physiological Society 1960
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THE ROLE OF THE LYMPHATICS IN THE INTESTINAL ABSORPTION OF VITAMIN B12 IN THE RAT

K. B. Taylor 1 and J. E. French 1

1 Nuffield Department of Clinical Medicine, University of Oxford and the Sir William Dunn School of Pathology, University of Oxford

The intestinal lymphatics play only a small part in the absorption of vitamin B12 from the gut in the rat. The activity which appears in the intestinal lymph after a small dose of the labelled vitamin (5 µmg.) is probably due mainly to recirculation and transfer from the plasma. When ten times this dose is given, there is a higher concentration of activity in lymph than in plasma, which suggests that there is then direct uptake by the lymph from the intestinal wall.

Note:

We are grateful to Miss M. Hoffmann for skilled assistance. This work was supported in part by a grant to Professor Witts by the Medical Research Council.

Submitted on July 23, 1959






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Copyright © 1960 by the The Physiological Society.