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Quarterly Journal of Experimental Physiology and Cognate Medical Sciences 45.1 pp 82-87
© The Physiological Society 1960
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RENAL DISEASE AND SECONDARY POTASSIUM DEPLETION IN AGEING RATS

G. C. Kennedy 1, C. T. G. Flear 1, and R. A. Parker 1

1 Medical Research Council, Department of Experimental Medicine and Department of Pathology, University of Cambridge

Rats, which were fed on a diet deficient in potassium for 5 weeks and then refed with normal food, replaced within 4 weeks the potassium lost from their muscles. Chronic renal lesions developed, and with their extension potassium was again lost from the muscles. Both the chronic renal damage and the potassium loss were more severe in adult than in young rats. At all ages, moreover, the renal lesions resembled those which develop spontaneously in senile rats, and which are also associated with potassium loss from the muscles. Possible reasons for this secondary potassium loss are discussed.

Note:

We wish to thank Mr. Brian Misson for carrying out the electrolyte determinations.

Submitted on August 31, 1959






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Copyright © 1960 by the The Physiological Society.