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Quarterly Journal of Experimental Physiology and Cognate Medical Sciences 45.2 pp 123-128
© The Physiological Society 1960
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THE EFFECT OF VARYING THE INSPIRED OXYGEN AND CARBON DIOXIDE PRESSURES ON THE CARDIAC OUTPUT OF THE UNANÆSTHETIZED RABBIT

P. I. Korner 1 and A. W. T. Edwards 2

1 Cardiopulmonary Research Unit, Department of Physiology, University of Sydney, Sydney, Australia
2 Cardiopulmonary Research Unit, Department of Physiology, University of Sydney, Sydney, Australia; Sydney Hospital Fellow in Cardiology

An experiment was carried out on twenty-four rabbits in which the inspired O2 was either 50 per cent, 21 per cent or 10 per cent and the inspired CO2O per cent or 5 per cent. High arterial pO2 or prolonged respiratory stimulation by CO2 resulted in no significant change in cardiac output, blood pressure or heart rate during the steady state. With 10 per cent O2+5 per cent CO2 there was a significant fall in cardiac output.

Note:

We are grateful to Miss Y. Hodgkinson for her assistance with the experiments.

Submitted on August 20, 1959






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Copyright © 1960 by the The Physiological Society.