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Quarterly Journal of Experimental Physiology and Cognate Medical Sciences 48.1 pp 61-66
© The Physiological Society 1963
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THE EFFECT OF CHOLESTEROL-FAT FEEDING ON THE ACTIVITY OF RABBIT AORTA DEHYDROGENASE SYSTEMS

O. Mrhová 1, T. Zemplényi 1, and Z. Lojda 1

1 Institute for Cardiovascular Research, Prague-Krccaron and the Angiological Laboratory of Charles University, Prague

The activity of some aorta dehydrogenase systems (lactic acid dehydrogenase, alpha-glycerophosphate dehydrogenase, succinic acid dehydrogenase and malic acid dehydrogenase) has been determined biochemically in early stages of experimental cholesterol atherosclerosis in rabbits. A method using neotetrazolium as the acceptor of electrons was applied. LDH activity was also determined spectrophotometrically. There was a significant decrease of SDH activity (p < 0·01) as early as 4 weeks and also 10 weeks after the start of cholesterol feeding. The activity of the dehydrogenase systems revealed a decrease of borderline significance (p < 0·05) 4 weeks (AGPDH) and 10 weeks (LDH, MDH) following daily administration of the cholesterol-fat diet.

Note:

The authors would like to thank Mrs. B. Buriánová for statistical calculations, Mrs. I. KníZková, Mrs. M. Krabcová and Mrs. E. Procházková for technical assistance. NT was kindly supplied by Dr. Z. Pádr, DPNH by Dr. J. Scaronkoda and samples of TC-G Boehringer test by C. F. Boehringer und Soehne, Ltd., Mannheim.

Submitted on October 22, 1962






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Copyright © 1963 by the The Physiological Society.