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Quarterly Journal of Experimental Physiology and Cognate Medical Sciences 53.1 pp 65-75
© The Physiological Society 1968
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A METHOD FOR THE ESTIMATION OF THE UMBILICAL BLOOD FLOW IN UNSTRESSED SHEEP AND GOATS WITH SOME RESULTS OF ITS APPLICATION

C. Crenshaw 1, L. B. Curet 1, L. Mannn 1, D. H. Barron 1, and W. E. Huckabee 2

1 Department of Physiology, Yale University School of Medicine, New Haven, Connecticut
2 Department of Medicine, Boston, Massachusetts

Experiments were carried out to test the applicability of the ‘diffusion equilibrium’ technique to the estimation of the rate of umbilical blood flow in unstressed ewes and does (female goats) in the last third of gestation. Antipyrine was infused into the maternal circulation for 5-7 min. whilst the concentration difference across the umbilical circuit was followed for 30 min. during which it rose and then fell to insignificance. A comparison of the concentrations of antipyrine in umbilical blood and fetal tissue at the 30th min. indicated such a degree of agreement that blood concentration can be substituted for tissue concentration as the numerator in the equation expressing the Fick principle. Results of the application of the method in both acute and chronic experiments are presented, together with data on the v-a oxygen difference across the umbilical circuit and the oxygen consumption of the fetus in utero.

Note:

It is a pleasure to acknowledge the help and advice of Dr. Giacomo Meschia in the early stages of this work.

This study was aided by grants from the National Institutes of Health (Nos. HD 02300 and HD02345-09) and the Association for the Aid of Crippled Children.

Submitted on April 24, 1967






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Copyright © 1968 by the The Physiological Society.