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Quarterly Journal of Experimental Physiology and Cognate Medical Sciences 53.2 pp 170-174
© The Physiological Society 1968
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THE EFFECT OF VAGAL STIMULATION AND ESERINE ON ISOLATED GUINEA-PIG OEligSOPHAGUS

A. L. Bartlet 1

1 Department of Veterinary Pharmacology, Royal (Dick) School of Veterinary Studies, Edinburgh

The response of the isolated oeligsophagus to vagal stimulation was blocked by tubocurarine, decamethonium or nicotine, and was partially antagonized by hyoscine or hexamethonium. The response of the separated external muscle to vagal stimulation was antagonized by tubocurarine or decamethonium, but not by hyoscine or hexamethonium. The muscularis mucosæ and the oeligsophagus contracted to eserine, 5 µg./ml., after a delay of 2-3 min., but the external muscle did not. Hyoscine antagonized eserine acting on the oeligsophagus or muscularis mucosæ.

Submitted on October 25, 1967






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Copyright © 1968 by the The Physiological Society.