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Quarterly Journal of Experimental Physiology and Cognate Medical Sciences 55.1 pp 36-43
© The Physiological Society 1970
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ACTION OF OXYTHIAMINE AND PYRITHIAMINE ON THE ISOLATED RAT SUPERIOR CERVICAL GANGLION

V. Perri 1, O. Sacchi 1, and C. Casella 1

1 Institutes of General Physiology and Human Physiology, University of Pavia, Italy

Incubation of isolated preparations of the superior cervical ganglion of the rat in the presence of low concentrations of oxythiamine and pyrithiamine results in an early and pronounced decrease of the post-ganglionic potential. This effect is particularly evident with regard to oxythiamine.

The depressant action of both antithiamines on ganglion transmission appears to be specifically due to their metabolic competition because it can be completely prevented by the presence of equimolecular amounts of thiamine in the incubating medium.

Note:

This research was partly supported by a Grant from the Richardson Merrell S.p.A., Naples.

Submitted on March 3, 1969






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Copyright © 1970 by the The Physiological Society.