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Quarterly Journal of Experimental Physiology and Cognate Medical Sciences 56.2 pp 113-122
© The Physiological Society 1971
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THE INFLUENCE OF CHRONIC ADMINISTRATION OF PENTAGASTRIN ON THE RAT PANCREAS

P. D. Mayston 1 and J. A. Barrowman 1

1 Department of Physiology, The London Hospital Medical College, London, E.1

Chronic administration of pentagastrin to rats results in hypertrophy of the acinar cells of the pancreas. This hypertrophy is accompanied by a decrease in the specific activities of pancreatic enzymes of the tissue in terms of protein content, and an increase in the RNA : DNA ratio of the tissue. An increase in weight of a duodenal segment has also been observed. The suggestion is put forward that the tetrapeptide, Try-Met-Asp-Phe-NH2, the sequence occurring at the carboxyl terminus of gastrin and cholecystokinin, may exert a trophic influence upon several tissues of the upper gastrointestinal tract.

Note:

We wish to thank Dr J. D. Fitzgerald of I.C.I. Ltd. for the generous supply of pentagastrin. The work was supported by a grant from the Wellcome Trust to Dr J. A. Barrowman. We are extremely grateful to Miss Anne Dand for excellent technical assistance.

Submitted on November 11, 1970




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H. C. Aras and J. Ekstrom
Pentagastrin-induced protein synthesis in the parotid gland of the anaesthetized rat, and its dependence on CCK-A and -B receptors and nitric oxide generation
Exp Physiol, July 1, 2006; 91(4): 673 - 679.
[Abstract] [Full Text] [PDF]


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