EFFECT OF PYLOROTOMY ON THE INTESTINAL PHASE OF GASTRIC SECRETION

¹ Nutrition Division, Food Laboratory U.S. Army Natick Laboratories Natick, Massachusetts 01760 and Department of Physiology, Jefferson Medical College, Philadelphia, Pennsylvania

In order to investigate the role of continuity of the pylorus-duodenal junction for the intestinal phase of gastric secretion, dogs were prepared with a chronic gastric fistula and an intestinal catheter, and gastric secretion measured during infusion of various materials into the intestine. In the fasted dog, protein hydrolysate solution infused into the intestine increases total acid output and pepsin markedly, but infusion of equiosmolar sodium chloride solution did not. Section of the pyloric sphincter with end-to-end anastomosis initially abolished the response to the protein hydrolysate, but it started to return after 7 post-operative days. Section of the stomach at the corpus-antral junction reduced the response to the protein hydrolysate for the first 7 days. The period of reduced response for both surgical procedures was of the same duration, 7 days.

Note:

The authors are indebted to Dr E. J. Zawoiski of Thomas Jefferson University, Philadelphia, Pennsylvania, for helpful criticisms and suggestions.

This paper reports research undertaken at the U.S. Army Natick (Mass.) Laboratories and has been assigned TP-1155 in the series of papers approved for publication. The findings in this report are not to be construed as an official Department of the Army position.