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Quarterly Journal of Experimental Physiology 67.1 pp 7-15
© The Physiological Society 1982
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PAROTID DEGENERATION SECRETION OF AMYLASE IN VITRO IN THE RAT FOLLOWING SYMPATHECTOMY

B. Asking 1, N. Emmelin 1, P. Gjörstrup 1, and H. Pärsson 1

1 Institute of Physiology and Biophysics, University of Lund, Sweden

After extirpation of the superior cervical ganglion in the rat a degeneration secretion of amylase occurs in an in vitro preparation of the parotid gland. It can be detected about 14 h after the sympathectomy, reaches a maximum after about 17 h and then slowly subsides. It is abolished by atenolol, but not by dihydroergotamine or atropine, nor by tetrodotoxin. From this it is concluded that the phenomenon is due to an action mainly on beta1-adrenoceptors exerted by noradrenaline, which is released from the degenerating sympathetic nerves at the neuro-glandular junctions, independently of propagated nerve impulses.

Submitted on April 21, 1981







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Copyright © 1982 by the The Physiological Society.