Experimental Physiology
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Quarterly Journal of Experimental Physiology 68.2 pp 247-258
© The Physiological Society 1983
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EFFECTS OF ADRENALINE AND NORADRENALINE ON GLUCOSE-INDUCED ELECTRICAL ACTIVITY OF MOUSE PANCREATIC beta CELL

Sonia Santana De Sa 1, Rosa Ferrer 2, Eduardo Rojas 2, and Illani Atwater 2

1 Department of Human Biology, University of Surrey, Guildford, U.K.
2 Department of Biophysics, School of Biological Sciences, University of East Anglia, Norwich, NR4 7TJ, U.K.

The effects of adrenaline and noradrenaline on membrane potential and glucose-induced electrical activity were studied in micro-dissected mouse Islets of Langerhans. Both catecholamines induced hyperpolarization and blocked electrical activity in the presence of 11·1 mM glucose. Phentolamine, but not propranalol, blocked these effects, indicating predominantly agr receptor action. Quinine, but not tetraethylammonium ions, antagonized the inhibitory effects of the catecholamines. The data are consistent with the hypothesis that agr receptor activation induces a transient increase in intracellular Ca2+ concentration which in turn leads to an increase in K+ permeability.

Submitted on August 23, 1982




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Copyright © 1983 by the The Physiological Society.