Experimental Physiology
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Quarterly Journal of Experimental Physiology 69.3 pp 507-519
© The Physiological Society 1984
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SODIUM CURRENTS IN SKELETAL MUSCLE FIBRES FROM THE TOAD BUFO MARINUS

N. J. Arispe 1, J. A. Argibay 1, and L. V. Rojas 1

1 Facultad de Ciencias, Universidad Central de Venezuela, Apartado 21201, Caracas 1020A, Venezuela

Single fibres from the sartorius muscle of the toad Bufo marinus were used to study ionic currents, using a fast voltage-clamp method. Sodium currents were analysed following Hodgkin-Huxley formulations. Internal caesium fluoride blocks delayed currents but produced shifts in the equilibrium potential of the early channel due to sodium accumulation. Delayed channels are very unstable when fluoride is used inside the fibre. These instabilities and equilibrium potential shifts were eliminated on replacing fluoride by aspartate in the internal solution. Late peaks of inward current, probably associated with activity at the tubular system, were occasionally observed for small depolarizations. The results are compared with those obtained for other amphibian species and used to explain more general electrophysiological properties of muscle fibres of this tropical toad.

Submitted on August 29, 1983






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Copyright © 1984 by the The Physiological Society.