INFLUENCE OF INTRADUODENAL GLUCOSE ON MEAL SIZE AND ITS MODIFICATION BY 2-DEOXY-D-GLUCOSE OR VAGOTOMY IN HUNGRY PIGS

¹ AFRC Institute of Animal Physiology, Babraham, Cambridge CB2 4AT

Young growing pigs which had been trained to press a panel in order to obtain small deliveries of food and adapted to eating all their food in one meal per day were surgically fitted with an exteriorized cannula connected to the duodenum. An infusion of 250 ml 150% (w/v) glucose solution 10 min before the meal did not influence meal size, whereas a similar infusion shortly after beginning a meal significantly reduced meal size. When the membrane transport and metabolism of glucose was reduced by infusing the antimetabolite, 2-deoxy-D-glucose, before the glucose infusion, the suppression of appetite was attenuated. Intrathoracic truncal vagotomy abolished the effects of intraduodenal glucose. The possibility that a receptor sensitive to transport and metabolism of glucose exists in the duodenum is discussed.

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