Experimental Physiology
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Quarterly Journal of Experimental Physiology 71.3 pp 483-489
© The Physiological Society 1986
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THE INFLUX OF ASCORBIC ACID INTO THE RAT'S BRAIN

D. K. C. Lam 1 and P. M. Daniel 2

1 Division of Biochemistry, United Medical and Dental Schools, St Thomas's Hospital Medical School, London, SE1 7EH
2 Department of Applied Physiology and Surgical Sciences, Royal College of Surgeons, Lincoln's Inn Fields, WC2A 3PN

The influx of [14C]ascorbic acid into the rat's brain through the cerebral capillaries was measured by the steady-state initial-rate technique. Ascorbic acid was found to pass through the capillaries by a carrier-mediated process and by simple diffusion. The carrier system was found to have an apparent Vmax of 1·2 nmol. min-1. g-1 of cerebral tissue and a Kt of 125 µM. The apparent constant of transfer, Kd, of the diffusional component was 0·98 µl. min-1. g-1. The contribution of the cerebral capillaries to the movement of ascorbic acid into the brain is discussed and was found to be the major route of entry into the brain for this vitamin.

Submitted on October 15, 1985






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Copyright © 1986 by the The Physiological Society.