Experimental Physiology
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Quarterly Journal of Experimental Physiology 72.2 pp 215-225
© The Physiological Society 1987
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EFFECT OF DRUGS, HORMONES AND ELECTRICAL FIELD STIMULATION ON ISOLATED MUSCLE STRIPS FROM HUMAN CHOLEDOCHODUODENAL JUNCTION

H. C. McKirdy 1, R. W. Marshall 1, and P. Griffin 2

1 Departments of Surgery and Pharmacology, University of Wales College of Medicine, Heath Park, Cardiff CF4 4XN
2 Transplant Unit, Cardiff Royal Infirmary, Newport Road, Cardiff CF2 1SZ

The behaviour of in vitro strips from the human choledochoduodenal junction would appear to be related to the anatomical location of origin of the strip. Strips from the papillary region showed low tone and obvious spontaneous rhythmic contractions (0·5-6/min). Strips from the region of the inferior choledochal sphincter showed, in ten out of fifteen specimens, spontaneous myogenic tone and gave a relaxation or a biphasic response (relaxation followed by contraction) to electrical field stimulation (0·3 ms pulses at 10 Hz for 5 s). All strips from human choledochoduodenal junction are remarkably insensitive to a variety of gastrointestinal hormones and to opioid agents.

Submitted on June 20, 1986






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Copyright © 1987 by the The Physiological Society.