FLOW THROUGH INTERSTITIUM AND OTHER FIBROUS MATRICES

¹ Department of Physiology, St George's Hospital Medical School, London SW17 0RE

This review examined the relation between interstitial hydraulic permeability and chemical composition, using porous matrix theory, and assessed the view that interstitial conductivity is governed by GAG concentration. Conductivity correlates negatively with both GAG and collagen concentration over a wide variety of tissues. Conductivities of GAG matrices in vitro, coupled with other quantitative considerations, indicate, however, that no single class of fixed fibrous element exists at a sufficiently high concentration to account by itself for the low conductivity in most tissues. It seems that the low interstitial conductivity arises from the combined interactive effects of three main classes of fibrous element: collagen fibrils, GAG and proteoglycan core protein. In most cases the proteoglycan complex plays a major role which is significantly amplified, however, by the collagen fibril network.

This article has been cited by other articles:

				J. M. Stewart, D. S. Schultz, O.-T. Lee, and M. L. Trinidad Exogenous Collagen Cross-linking Reduces Scleral Permeability: Modeling the Effects of Age-Related Cross-link Accumulation Invest. Ophthalmol. Vis. Sci., January 1, 2009; 50(1): 352 - 357. [Abstract] [Full Text] [PDF]

				T. L. Jackson, A. Hussain, A. M. S. Morley, P. M. Sullivan, A. Hodgetts, A. El-Osta, J. Hillenkamp, S. J. Charles, R. Sheard, T. H. Williamson, et al. Scleral Hydraulic Conductivity and Macromolecular Diffusion in Patients with Uveal Effusion Syndrome Invest. Ophthalmol. Vis. Sci., November 1, 2008; 49(11): 5033 - 5040. [Abstract] [Full Text] [PDF]

				S. F. Roberts, J. G. Stinstra, and C. S. Henriquez Effect of Nonuniform Interstitial Space Properties on Impulse Propagation: A Discrete Multidomain Model Biophys. J., October 15, 2008; 95(8): 3724 - 3737. [Abstract] [Full Text] [PDF]

				D. G. Struijk Monitoring of the peritoneal membrane NDT Plus, October 1, 2008; 1(suppl_4): iv29 - iv35. [Abstract] [Full Text] [PDF]

				W. J. McCarty, M. F. Chimento, C. A. Curcio, and M. Johnson Effects of particulates and lipids on the hydraulic conductivity of Matrigel J Appl Physiol, August 1, 2008; 105(2): 621 - 628. [Abstract] [Full Text] [PDF]

				K. J. Mattern, C. Nakornchai, and W. M. Deen Darcy Permeability of Agarose-Glycosaminoglycan Gels Analyzed Using Fiber-Mixture and Donnan Models Biophys. J., July 15, 2008; 95(2): 648 - 656. [Abstract] [Full Text] [PDF]

				S. Nagano, J. Y. Perentes, R. K. Jain, and Y. Boucher Cancer Cell Death Enhances the Penetration and Efficacy of Oncolytic Herpes Simplex Virus in Tumors Cancer Res., May 15, 2008; 68(10): 3795 - 3802. [Abstract] [Full Text] [PDF]

				D. R. Potter and E. R. Damiano The Hydrodynamically Relevant Endothelial Cell Glycocalyx Observed In Vivo Is Absent In Vitro Circ. Res., April 11, 2008; 102(7): 770 - 776. [Abstract] [Full Text] [PDF]

				M. Magzoub, S. Jin, and A. S. Verkman Enhanced macromolecule diffusion deep in tumors after enzymatic digestion of extracellular matrix collagen and its associated proteoglycan decorin FASEB J, January 1, 2008; 22(1): 276 - 284. [Abstract] [Full Text] [PDF]

				J. W. Ji, F. Mac Gabhann, and A. S. Popel Skeletal muscle VEGF gradients in peripheral arterial disease: simulations of rest and exercise Am J Physiol Heart Circ Physiol, December 1, 2007; 293(6): H3740 - H3749. [Abstract] [Full Text] [PDF]

				A. Oldberg, S. Kalamajski, A. V. Salnikov, L. Stuhr, M. Morgelin, R. K. Reed, N.-E. Heldin, and K. Rubin Collagen-binding proteoglycan fibromodulin can determine stroma matrix structure and fluid balance in experimental carcinoma PNAS, August 28, 2007; 104(35): 13966 - 13971. [Abstract] [Full Text] [PDF]

				Z. Zeng, Y. Yin, K.-M. Jan, and D. S. Rumschitzki Macromolecular transport in heart valves. II. Theoretical models Am J Physiol Heart Circ Physiol, June 1, 2007; 292(6): H2671 - H2686. [Abstract] [Full Text] [PDF]

				F. Mac Gabhann, J. W. Ji, and A. S. Popel VEGF gradients, receptor activation, and sprout guidance in resting and exercising skeletal muscle J Appl Physiol, February 1, 2007; 102(2): 722 - 734. [Abstract] [Full Text] [PDF]

				S. Sabaratnam, P. J. Coleman, R. M. Mason, and J. R. Levick Interstitial matrix proteins determine hyaluronan reflection and fluid retention in rabbit joints: effect of protease J. Physiol., January 1, 2007; 578(1): 291 - 299. [Abstract] [Full Text] [PDF]

				T. L. Jackson, A. Hussain, A. Hodgetts, A. M. S. Morley, J. Hillenkamp, P. M. Sullivan, and J. Marshall Human Scleral Hydraulic Conductivity: Age-Related Changes, Topographical Variation, and Potential Scleral Outflow Facility Invest. Ophthalmol. Vis. Sci., November 1, 2006; 47(11): 4942 - 4946. [Abstract] [Full Text] [PDF]

				M. E. Fleury, K. C. Boardman, and M. A. Swartz Autologous Morphogen Gradients by Subtle Interstitial Flow and Matrix Interactions Biophys. J., July 1, 2006; 91(1): 113 - 121. [Abstract] [Full Text] [PDF]

				M. F. Flessner, J. Choi, H. Vanpelt, Z. He, K. Credit, J. Henegar, and M. Hughson Correlating structure with solute and water transport in a chronic model of peritoneal inflammation Am J Physiol Renal Physiol, January 1, 2006; 290(1): F232 - F240. [Abstract] [Full Text] [PDF]

				S. Sabaratnam, V. Arunan, P. J. Coleman, R. M. Mason, and J. R. Levick Size selectivity of hyaluronan molecular sieving by extracellular matrix in rabbit synovial joints J. Physiol., September 1, 2005; 567(2): 569 - 581. [Abstract] [Full Text] [PDF]

				M. F. Flessner The transport barrier in intraperitoneal therapy Am J Physiol Renal Physiol, March 1, 2005; 288(3): F433 - F442. [Abstract] [Full Text] [PDF]

				R. J. Filion and A. S. Popel Intracoronary administration of FGF-2: a computational model of myocardial deposition and retention Am J Physiol Heart Circ Physiol, January 1, 2005; 288(1): H263 - H279. [Abstract] [Full Text] [PDF]

				J. P. Alberding, A. L. Baldwin, J. K. Barton, and E. Wiley Onset of pulsatile pressure causes transiently increased filtration through artery wall Am J Physiol Heart Circ Physiol, May 1, 2004; 286(5): H1827 - H1835. [Abstract] [Full Text] [PDF]

				C. A. Znati, M. Rosenstein, T. D. McKee, E. Brown, D. Turner, W. D. Bloomer, S. Watkins, R. K. Jain, and Y. Boucher Irradiation Reduces Interstitial Fluid Transport and Increases the Collagen Content in Tumors Clin. Cancer Res., November 15, 2003; 9(15): 5508 - 5513. [Abstract] [Full Text] [PDF]

				C. P. Ng and M. A. Swartz Fibroblast alignment under interstitial fluid flow using a novel 3-D tissue culture model Am J Physiol Heart Circ Physiol, May 1, 2003; 284(5): H1771 - H1777. [Abstract] [Full Text] [PDF]

				S. Ramanujan, A. Pluen, T. D. McKee, E. B. Brown, Y. Boucher, and R. K. Jain Diffusion and Convection in Collagen Gels: Implications for Transport in the Tumor Interstitium Biophys. J., September 1, 2002; 83(3): 1650 - 1660. [Abstract] [Full Text] [PDF]

				M. F. Flessner Transport of protein in the abdominal wall during intraperitoneal therapy. I. Theoretical approach Am J Physiol Gastrointest Liver Physiol, August 1, 2001; 281(2): G424 - G437. [Abstract] [Full Text] [PDF]

				S. McGuire and F. Yuan Quantitative analysis of intratumoral infusion of color molecules Am J Physiol Heart Circ Physiol, August 1, 2001; 281(2): H715 - H721. [Abstract] [Full Text] [PDF]

				F. Bodega, L. Zocchi, and E. Agostoni Macromolecule transfer through mesothelium and connective tissue J Appl Physiol, December 1, 2000; 89(6): 2165 - 2173. [Abstract] [Full Text] [PDF]

				X.-Y. Zhang, J. Luck, M. W. Dewhirst, and F. Yuan Interstitial hydraulic conductivity in a fibrosarcoma Am J Physiol Heart Circ Physiol, December 1, 2000; 279(6): H2726 - H2734. [Abstract] [Full Text] [PDF]

				E. R. Zakaria, J. Lofthouse, and M. F. Flessner Effect of intraperitoneal pressures on tissue water of the abdominal muscle Am J Physiol Renal Physiol, June 1, 2000; 278(6): F875 - F885. [Abstract] [Full Text] [PDF]

				P. A. Netti, D. A. Berk, M. A. Swartz, A. J. Grodzinsky, and R. K. Jain Role of Extracellular Matrix Assembly in Interstitial Transport in Solid Tumors Cancer Res., May 1, 2000; 60(9): 2497 - 2503. [Abstract] [Full Text]

				E. Agostoni, F. Bodega, and L. Zocchi Equivalent radius of paracellular "pores" of the mesothelium J Appl Physiol, August 1, 1999; 87(2): 538 - 544. [Abstract] [Full Text] [PDF]

				J. M. Tarbell, L. Demaio, and M. M. Zaw Effect of pressure on hydraulic conductivity of endothelial monolayers: role of endothelial cleft shear stress J Appl Physiol, July 1, 1999; 87(1): 261 - 268. [Abstract] [Full Text] [PDF]

				C. C. Michel and F. E. Curry Microvascular Permeability Physiol Rev, July 1, 1999; 79(3): 703 - 761. [Abstract] [Full Text] [PDF]

				H. DEMISSACHEW, J. LOFTHOUSE, and M. F. FLESSNER Tissue Sources and Blood Flow Limitations of Osmotic Water Transport Across the Peritoneum J. Am. Soc. Nephrol., February 1, 1999; 10(2): 347 - 353. [Abstract] [Full Text]

				E. R. Zakaria, J. Lofthouse, and M. F. Flessner In vivo effects of hydrostatic pressure on interstitium of abdominal wall muscle Am J Physiol Heart Circ Physiol, February 1, 1999; 276(2): H517 - H529. [Abstract] [Full Text] [PDF]

				T. W. Secomb, R. Hsu, and A. R. Pries A model for red blood cell motion in glycocalyx-lined capillaries Am J Physiol Heart Circ Physiol, March 1, 1998; 274(3): H1016 - H1022. [Abstract] [Full Text] [PDF]

				E. R. Zakaria, J. Lofthouse, and M. F. Flessner In vivo hydraulic conductivity of muscle: effects of hydrostatic pressure Am J Physiol Heart Circ Physiol, December 1, 1997; 273(6): H2774 - H2782. [Abstract] [Full Text] [PDF]

				K. Aukland, H. Wiig, O. Tenstad, and E. M. Renkin Interstitial exclusion of macromolecules studied by graded centrifugation of rat tail tendon Am J Physiol Heart Circ Physiol, December 1, 1997; 273(6): H2794 - H2803. [Abstract] [Full Text] [PDF]

				A. Pluen, Y. Boucher, S. Ramanujan, T. D. McKee, T. Gohongi, E. di Tomaso, E. B. Brown, Y. Izumi, R. B. Campbell, D. A. Berk, et al. Role of tumor-host interactions in interstitial diffusion of macromolecules: Cranial vs. subcutaneous tumors PNAS, April 10, 2001; 98(8): 4628 - 4633. [Abstract] [Full Text] [PDF]