Experimental Physiology
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Quarterly Journal of Experimental Physiology 73.1 pp 135-138
© The Physiological Society 1988
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IS VIP THE PUTATIVE NON-CHOLINERGIC, NON-ADRENERGIC NEUROTRANSMITTER CONTROLLING PROTEIN SECRETION IN RAT LACRIMAL GLANDS?

Munir Hussain 1 and Jaipaul Singh 1

1 School of Applied Biology, Lancashire Polytechnic, Preston PRJ 2TQ

In the combined presence of cholinergic and adrenergic antagonists, electrical field stimulation (FS) caused a marked reversible increase in protein output from superfused rat lacrimal gland segments. The FS-evoked protein output was abolished by the nerve blocking drug tetrodotoxin (TTX; 10-6 M) whereas high potassium (K+; 100 mM) continued to elicit secretion. Vasoactive intestinal polypeptide (VIP), but not adenosine 5'-triphosphate (ATP), stimulated protein secretion in a manner almost identical to that observed in response to FS. The results suggest that the non-cholinergic, non-adrenergic secretory response may involve VIP as an endogenous neurotransmitter.

Submitted on October 19, 1987
Accepted on October 26, 1987






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Copyright © 1988 by the The Physiological Society.