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Quarterly Journal of Experimental Physiology 73.3 pp 391-397
© The Physiological Society 1988
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FEED-BACK INHIBITION OF MILK SECRETION: THE EFFECT OF A FRACTION OF GOAT MILK ON MILK YIELD AND COMPOSITION

Colin J. Wilde 1, Caroline V. P. Addey 1, David R. Blatchford 1, Malcolm Peaker 1, and Michael J. Casey 2

1 Hannah Research Institute, Ayr KA6 5HL
2 Department of Veterinary Physiology and Biochemistry, University College, Dublin, Eire

A milk fraction containing whey proteins of 10-30 kDa was injected into one mammary gland of lactating goats via the teat canal. This fraction produced a temporary dose-dependent reduction in milk yield in the treated gland; the milk yield of the other gland, which received an equal volume of carrier solution, was not affected. Injection of a second fraction, containing whey proteins of rang 30 kDa, affected milk secretion only at high doses, and this effect was not wholly specific to the treated gland. The 10-30 kDa fraction and the rang 30 kDa fraction produced similar transient changes in the concentrations of several ions and lactose in milk of the treated gland, but not in that of the untreated gland. These data indicate that a milk constituent present in the 10-30 kDa whey inhibits milk secretion in a temporary and reversible manner. The results are discussed in relation to regulation of milk secretion through local feed-back inhibition.

Submitted on September 29, 1987
Accepted on November 26, 1987




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