‘PARALYTIC’ SECRETION AFTER PARASYMPATHECTOMY OF RABBIT SUBMANDIBULAR GLANDS INCLUDES A CHOLINERGIC COMPONENT

¹ Department of Oral Pathology, The Rayne Institute, King's College School of Medicine and Dentistry, London SE5 9NU
² Pathology Department, College of Medicine, King Saud University, Riyadh, Saudi Arabia

Chronic parasympathetic decentralization of submandibular glands in rabbits has been studied after 3 weeks, in acute experiments under urethane anaesthesia. A ‘paralytic’ secretion occurred from the supersensitive denervated glands and it was not attributable to an increase in the ‘spontaneous’ flow, that is present in normal glands. The ‘paralytic’ secretion was completely inhibited by atropine, after which a ‘spontaneous’ flow, that was similar to the contralateral glands, persisted. The -adrenergic blocker dihydroergotamine, when given before atropine, reduced the ‘paralytic’ secretion by 50-75% but when this drug was given after atropine it had no additional effect. The -adrenergic blocker propanolol did not cause a reduction in the ‘paralytic’ secretion. Superior cervical ganglionectomy, in contrast, did not give rise to a significant ‘paralytic’ flow. The results suggest that acetylcholine, released spontaneously from terminals of postganglionic parasympathetic nerves, plays an essential part in the ‘paralytic’ secretion that occurs from rabbit submandibular glands after preganglionic denervation. Circulating catecholamines make a secondary contribution, acting synergistically with the acetylcholine on the supersensitive secretory cells.

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