Experimental Physiology
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Quarterly Journal of Experimental Physiology 73.5 pp 777-780
© The Physiological Society 1988
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TESTING THE HYPOTHESIS THAT CRYPT CELL HYPERPLASIA INHIBITS LACTASE EXPRESSION BY MOUSE JEJUNAL ENTEROCYTES

M. W. Smith 1, S. Lloyd 2, and P. S. James 1

1 Department of Cell Biology, AFRC Institute of Animal Physiology and Genetics Research, Babraham, Cambridge CB2 4AT
2 Department of Clinical Veterinary Medicine, University of Cambridge, Cambridge CB3 0ES

Lactase activity and crypt cell proliferation both increased significantly in mouse jejunal villi in the presence of the intestinal parasite Nematospiroides dubius. Comparisons are made between this result and others showing lactase activity to decline whenever crypt cell proliferation is increased.

Submitted on May 17, 1988
Accepted on May 24, 1988






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Copyright © 1988 by the The Physiological Society.