Experimental Physiology
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Quarterly Journal of Experimental Physiology 73.5 pp 781-784
© The Physiological Society 1988
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FURTHER EVIDENCE FOR A PARATHYROID HORMONE-RELATED PROTEIN IN FETAL PARATHYROID GLANDS OF SHEEP

N. Loveridge 1, I. W. Caple 2, C. Rodda 3, T. J. Martin 3, and A. D. Care 4

1 Rowett Research Institute, Bucksburn, Aberdeen
2 Veterinary Clinical Sciences, University of Melbourne, Australia
3 Departments of Medicine, University of Melbourne, Australia
4 Department of Animal Physiology and Nutrition, University of Leeds, Leeds LS2 9JT

Extracts of ovine fetal parathyroid glands contained a substance in addition to parathyroid hormone (PTH) which could not be neutralized by antiserum against PTH in a cytochemical bioassay. This substance reacted similarly to human parathyroid hormone-related protein, the humoral hyper-calcaemic factor associated with malignancy in man. The ovine fetal PTHrP may be responsible for maintaining the fetus hypercalcaemic relative to the mother.

Submitted on June 20, 1988
Accepted on June 27, 1988






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Copyright © 1988 by the The Physiological Society.