Experimental Physiology
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Quarterly Journal of Experimental Physiology 73.5 pp 789-792
© The Physiological Society 1988
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A COMPARISON OF THE DISTRIBUTION OF SUBSTANCE P AND CALCITONIN GENE-RELATED PEPTIDE RECEPTORS IN THE RAT BLADDER

Alan J. Nimmo 1, John F. B. Morrison 1, and Elaine M. Whitaker 1

1 Department of Physiology, University of Leeds, Leeds LS2 9JT

Binding of [125I]Bolton-Hunter labelled substance P (BH-SP) and [125I]human agr-calcitonin gene-related peptide (hagrCGRP) to rat bladder tissue sections was characterized and the respective binding sites localized by light-microscopic autoradiography. BH-SP binding sites were localized to epithelium, blood vessels and smooth muscle while hCGRP binding sites were present only over the epithelium. These results suggest that the range of biological actions of substance P and calcitonin gene-related peptide, which may be co-released from the same afferent terminals, might be determined by the different distributions of their respective receptors.

Submitted on June 28, 1988
Accepted on July 4, 1988




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