Experimental Physiology
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Quarterly Journal of Experimental Physiology 73.5 pp 801-804
© The Physiological Society 1988
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REFLEX RESPONSES OF VASCULAR RESISTANCE IN ANAESTHETIZED DOGS TO INDEPENDENT CHANGES IN VENTRICULAR SYSTOLIC PRESSURE AND CARDIAC INOTROPIC STATE

S. M. Tutt 1, J. K. A. Al-Timman 1, and R. Hainsworth 1

1 Department of Cardiovascular Studies, University of Leeds, Leeds LS2 9JT

Responses of systemic arterial perfusion pressure to changes in ventricular systolic pressure were determined before and after administration of dobutamine, then after propranolol, to determine whether the effective stimulus to left ventricular receptors was the change in ventricular systolic pressure or inotropic state. The results showed that increases in ventricular systolic pressure resulted in reflex vasodilatation which was unaffected by inotropic state, indicating that changes in ventricular systolic pressure provided the more potent stimulus.

Submitted on July 4, 1988
Accepted on July 15, 1988






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Copyright © 1988 by the The Physiological Society.