Experimental Physiology
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Quarterly Journal of Experimental Physiology 73.6 pp 1017-1020
© The Physiological Society 1988
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THE EFFECTS OF NICKEL ON CONTRACTION AND MEMBRANE CURRENT IN ISOLATED RAT MYOCYTES

S. C. O'Neill 1, M. Valdeolmillos 1, and D. A. Eisner 1

1 Department of Physiology, University College London, Gower Street, London WC1E 6BT

Depolarization of isolated myocytes for several seconds produces a maintained, tonic component of tension. We have found that this is abolished by 5 mM-Ni2+. Furthermore if Ni2+ is applied after the tonic contraction has developed then its relaxation is prevented. These results are consistent with the hypothesis that Ni2+ inhibits Na+-Ca2+ exchange. Finally, also consistent with an inhibition of Na+-Ca2+ exchange, Ni2+ abolishes the transient inward current while having no effect on the underlying change of [Ca2+]i.

Submitted on August 19, 1988
Accepted on August 31, 1988




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