Experimental Physiology
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Quarterly Journal of Experimental Physiology 73.6 pp 1029-1031
© The Physiological Society 1988
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THYROID FUNCTION IN MALE ZUCKER RATS EXPOSED TO COLD

E. M. Whitaker 1, A. C. Robinson 1, K. M. Rayfield 1, and G. R. Hervey 1

1 Department of Physiology, University of Leeds, Leeds LS2 9NQ

Non-obese and obese Zucker rats were exposed to 6 °C for 20 days. At the end of the experiment thyroid stimulating hormone (TSH), circulating thyroid hormones, and the weights of the thyroid gland and a brown adipose tissue pad were measured. TSH and 3,5,3'-triiodothyronine concentrations and brown adipose tissue weights increased in response to cold in both phenotypes but by larger amounts in obese rats. Free thyroxine was lower in obese rats. There appears to be no defect in thyroid function in congenitally obese rats exposed to cold, or in their ability to develop brown adipose tissue.

Submitted on September 2, 1988
Accepted on September 9, 1988






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Copyright © 1988 by the The Physiological Society.