Experimental Physiology
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Quarterly Journal of Experimental Physiology 74.1 pp 19-26
© The Physiological Society 1989
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EFFECT OF MAGNESIUM INFUSION ON CALCIUM HANDLING IN THE RAT KIDNEY

I. Shafik 1 and R. Green 1

1 Department of Physiological Sciences, University of Manchester, Oxford Road, Manchester M13 9PT

Anaesthesized rats were infused with 100 µl min-1 of 0·9% saline or saline containing 2 or 4 mmol l-1 of magnesium chloride and renal function was studied. Magnesium had no effect on urine flow rate, excretion of sodium or potassium, or glomerular filtration rate (GFR). Infusion of either dose of magnesium increased calcium excretion and calcium concentration in the urine. The increased urinary calcium excretion is due to a decrease in tubular reabsorption of calcium.

Submitted on June 28, 1988
Accepted on August 4, 1988






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Copyright © 1989 by the The Physiological Society.