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Quarterly Journal of Experimental Physiology 74.2 pp 219-222
© The Physiological Society 1989
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NEW EVIDENCE THAT L-GLUTAMATE IS A TRANSMITTER AT THE SQUID GIANT SYNAPSE

A. De Santis 1 and J. B. Messenger 2

1 Stazione Zoologica, Naples, Italy
2 School of Biological Sciences, The University, Sheffield S10 2TN

Experiments are described showing unequivocally that transmission at the squid giant synapse can be reversibly blocked by L-glutamate and its agonists kainate, quisqualate and AMPA, though not by NMDA. This effect is presumably brought about by desensitization. The glutamate antagonists cis-2,3-PDA, GAMS and the new quinoxalinediones CNQX and DNQX are also potent reversible blockers. These findings provide new evidence that L-glutamate is a transmitter at the giant synapse and further suggest that the glutamate receptor may be of the non-NMDA type.

Submitted on December 19, 1988
Accepted on January 16, 1989




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[Abstract] [Full Text] [PDF]


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